药品详细

Candicidin(杀念菌素)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

杀念菌素

英文名

Candicidin

分子式

C₅₉H₈₄N₂O₁₈

化学名

33-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

分子量

Average: 1109.3009
Monoisotopic: 1108.571913894

CAS号

1403-17-4

ATC分类

G01A 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis.

生产厂家

Sanofi aventis us llc

封装厂家

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Aminoglycosides
Butyrophenones

Substructures

Carboxylic Acids and Derivatives
Aminoglycosides
Hydroxy Compounds
Alkanes and Alkenes
Pyrans
Acetates
Acetals and Derivatives
Keto-Acids
Lactones
Aliphatic and Aryl Amines
Ethers
Benzene and Derivatives
Butyrophenones
Amino Alcohols
Heterocyclic compounds
Aromatic compounds
Benzoyl Derivatives
Alcohols and Polyols
Acetophenones and Derivatives
Anilines
Ketones

适应症

药理

Indication	Used in the topical treatment of vulvovaginal candidiasis.
Pharmacodynamics	Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis.
Mechanism of action	Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Various Fungus Species
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
logP	1.7	Not Available

Predicted Properties

Property	Value	Source
water solubility	9.34e-03 g/l	ALOGPS
logP	-0.94	ALOGPS
logP	0.93	ChemAxon
logS	-5.1	ALOGPS
pKa (strongest acidic)	3.68	ChemAxon
pKa (strongest basic)	9.07	ChemAxon
physiological charge	0	ChemAxon
hydrogen acceptor count	19	ChemAxon
hydrogen donor count	11	ChemAxon
polar surface area	356.38	ChemAxon
rotatable bond count	10	ChemAxon
refractivity	300.5	ChemAxon
polarizability	119.88	ChemAxon

药物相互作用

食物相互作用

Not Available

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