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药品详细

Carbimazole(甲亢平)

化学结构式图
中文名
甲亢平
英文名
Carbimazole
分子式
C7H10N2O2S
化学名
ethyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate
分子量
Average: 186.232
Monoisotopic: 186.046298264
CAS号
22232-54-8
ATC分类
H03B Antithyroid preparations
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Carbamates and Derivatives
    Substructures
    • Carbamates and Derivatives
    • Ethers
    • Imidazoles
    • Heterocyclic compounds
    • Aromatic compounds
    • Cyanamides
    适应症
    药理
    Indication For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
    Pharmacodynamics Carbimazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.
    Mechanism of action Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding 85%
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 123.5 °C PhysProp
    logP 0.4 Not Available
    Predicted Properties
    Property Value Source
    water solubility 3.14e+00 g/l ALOGPS
    logP 0.78 ALOGPS
    logP 1.35 ChemAxon
    logS -1.8 ALOGPS
    pKa (strongest basic) -3 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 1 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 32.78 ChemAxon
    rotatable bond count 2 ChemAxon
    refractivity 49.17 ChemAxon
    polarizability 18.71 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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