药品详细
Cetirizine(西替利嗪)
化学结构式图
中文名
西替利嗪
英文名
Cetirizine
分子式
C21H25ClN2O3
化学名
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
分子量
Average: 388.888
Monoisotopic: 388.155370383
Monoisotopic: 388.155370383
CAS号
83881-51-0
ATC分类
R06A 未知;R06A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]
生产厂家
- Actavis elizabeth llc
- Actavis mid atlantic llc
- Amneal pharmaceuticals
- Amneal pharmaceuticals ny llc
- Apotex inc
- Aurobindo pharma ltd
- Banner pharmacaps inc
- Cadista pharmaceuticals inc
- Caraco pharmaceutical laboratories ltd
- Contract pharmacal corp
- Cypress pharmaceutical inc
- Dr reddys laboratories ltd
- Mcneil consumer healthcare div mcneil ppc inc
- Mylan pharmaceuticals inc
- Orchid healthcare
- Perrigo israel pharmaceuticals ltd
- Perrigo r and d co
- Pfizer inc
- Ranbaxy laboratories ltd
- Sandoz inc
- Sun pharmaceutical industries inc
- Taro pharmaceutical industries ltd
- Teva pharmaceuticals usa
- Torrent pharmaceuticals llc
- Unichem laboratories ltd
- Unique pharmaceutical laboratories
- Vintage pharmaceuticals llc
- Wockhardt ltd
封装厂家
- Actavis Group
- Advanced Pharmaceutical Services Inc.
- Apotex Inc.
- Apotheca Inc.
- AQ Pharmaceuticals Inc.
- Atlantic Biologicals Corporation
- Aurobindo Pharma Ltd.
- Bryant Ranch Prepack
- Caraco Pharmaceutical Labs
- Cardinal Health
- CVS Pharmacy
- Cypress Pharmaceutical Inc.
- Direct Dispensing Inc.
- Direct Pharmaceuticals Inc.
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Doctor Reddys Laboratories Ltd.
- EZ-EM Inc.
- H.J. Harkins Co. Inc.
- J.B. Chemicals & Pharmaceuticals
- Kaiser Foundation Hospital
- L Perrigo Co.
- Lake Erie Medical and Surgical Supply
- McNeil Laboratories
- Medvantx Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- Nucare Pharmaceuticals Inc.
- Ohm Laboratories Inc.
- PCA LLC
- PD-Rx Pharmaceuticals Inc.
- Perrigo Co.
- Pfizer Inc.
- Pharmacy Service Center
- Physicians Total Care Inc.
- Prepackage Specialists
- Prepak Systems Inc.
- Qualitest
- Ranbaxy Laboratories
- Redpharm Drug
- Resource Optimization and Innovation LLC
- Sandoz
- Southwood Pharmaceuticals
- Teva Pharmaceutical Industries Ltd.
- US Pharmaceutical Group
- Vangard Labs Inc.
- Warner Chilcott Co. Inc.
- Wockhardt Ltd.
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria |
| Pharmacodynamics | Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis. |
| Mechanism of action | Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain. |
| Absorption | mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine |
| Volume of distribution | Not Available |
| Protein binding | Very high (93%) plasma protein binding |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | 8.3 hours |
| Clearance |
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| Toxicity | Somnolence (sleepiness or unusual drowsiness), restlessness, irritability |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
- Avoid alcohol.
- Take without regard to meals.
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