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药品详细

Chlorphenesin(氯苯甘醚)

化学结构式图
中文名
氯苯甘醚
英文名
Chlorphenesin
分子式
C9H11ClO3
化学名
3-(4-chlorophenoxy)propane-1,2-diol
分子量
Average: 202.635
Monoisotopic: 202.039671925
CAS号
104-29-0
ATC分类
D01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)

生产厂家
  • Pharmacia and upjohn co
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8. Pubmed
  2. Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13. Pubmed
  3. Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Phenols and Derivatives
  • Ethers
  • Halobenzenes
  • Anisoles
  • Phenyl Esters
Substructures
  • Glycerol and Derivatives
  • Hydroxy Compounds
  • Phenols and Derivatives
  • Ethers
  • Benzene and Derivatives
  • Aryl Halides
  • Halobenzenes
  • Alcohols and Polyols
  • Aromatic compounds
  • Anisoles
  • Phenyl Esters
适应症
药理
Indication Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
Pharmacodynamics Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.
Mechanism of action The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.
Absorption Rapid and complete.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.
Route of elimination Not Available
Half life 2.3-5 hours
Clearance Not Available
Toxicity Symptoms of a chlorphenesin overdose include drowsiness and nausea.
Affected organisms
  • Humans and other mammals
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
melting point 78 °C PhysProp
water solubility 1E+004 mg/L MERCK INDEX (1996); less than
logP 1.2 Not Available
Predicted Properties
Property Value Source
water solubility 1.04e+01 g/l ALOGPS
logP 1.46 ALOGPS
logP 1.1 ChemAxon
logS -1.3 ALOGPS
pKa (strongest acidic) 13.62 ChemAxon
pKa (strongest basic) -3 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 3 ChemAxon
hydrogen donor count 2 ChemAxon
polar surface area 49.69 ChemAxon
rotatable bond count 4 ChemAxon
refractivity 49.58 ChemAxon
polarizability 20.1 ChemAxon
药物相互作用
Drug Interaction
Triprolidine The CNS depressants, Triprolidine and Chlorphenesin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
食物相互作用
Not Available

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