药品详细
Chlorprothixene(氯普噻吨)
化学结构式图
中文名
氯普噻吨
英文名
Chlorprothixene
分子式
C18H18ClNS
化学名
[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine
分子量
Average: 315.86
Monoisotopic: 315.084847978
Monoisotopic: 315.084847978
CAS号
113-59-7
ATC分类
N05A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
生产厂家
- Hoffmann la roche inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
药理
| Indication | For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. |
| Pharmacodynamics | Chlorprothixene is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine analgesic effects. An antiemetic effect, as with most antipsychotics, exists. It is used in the treatment of nervous, mental, and emotional conditions. Improvement in such conditions is thought to result from the effect of the medicine on nerve pathways in specific areas of the brain. Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side-effects. Chlorprothixene is structurally related to chlorpromazine, with which it shares in principal all side effects. Allergic side-effects and liver damage seem to appear with an appreciable lower frequency. |
| Mechanism of action | Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. |
| Absorption | Incomplete bioavailability. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Hepatic
|
| Route of elimination | Not Available |
| Half life | 8 to 12 hours |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose include difficulty in breathing (severe), dizziness (severe), drowsiness (severe), muscle trembling, jerking, stiffness, or uncontrolled movements (severe), small pupils, unusual excitement, and unusual tiredness or weakness (severe). |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Donepezil | Possible antagonism of action |
| Galantamine | Possible antagonism of action |
| Guanethidine | Chlorprothixene may decrease the effect of guanethidine. |
| Rivastigmine | Possible antagonism of action |
食物相互作用
- Avoid alcohol.
- Take with food to reduce irritation.
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