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药品详细

Clenbuterol(瘦肉精)

化学结构式图
中文名
瘦肉精
英文名
Clenbuterol
分子式
C12H18Cl2N2O
化学名
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol
分子量
Average: 277.19
Monoisotopic: 276.079618622
CAS号
37148-27-9
ATC分类
R03C 未知;R03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Benzyl Alcohols and Derivatives
    • Phenethylamines
    Substructures
    • Hydroxy Compounds
    • Benzyl Alcohols and Derivatives
    • Aliphatic and Aryl Amines
    • Benzene and Derivatives
    • Aryl Halides
    • Halobenzenes
    • Amino Alcohols
    • Phenethylamines
    • Aromatic compounds
    • Alcohols and Polyols
    • Anilines
    适应症
    药理
    Indication Used as a bronchodilator in the treatment of asthma patients.
    Pharmacodynamics Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. Although approved for use in some countries, as of fall, 2006, clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. Food and Drug Administration.
    Mechanism of action Clenbuterol is a Beta(2) agonist similar in some structural respects to salbutamol. Agonism of the beta(2) receptor stimulates adenylyl cyclase activity which ultimately leads to downstream effects of smooth muscle relaxation in the bronchioles.
    Absorption 89-98% orally
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life 36-39 hours
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.12e-01 g/l ALOGPS
    logP 2.94 ALOGPS
    logP 2.33 ChemAxon
    logS -3.4 ALOGPS
    pKa (strongest acidic) 14.06 ChemAxon
    pKa (strongest basic) 9.63 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 3 ChemAxon
    polar surface area 58.28 ChemAxon
    rotatable bond count 4 ChemAxon
    refractivity 73.38 ChemAxon
    polarizability 28.81 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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