药品详细
Tripelennamine(曲吡那敏)
化学结构式图
中文名
曲吡那敏
英文名
Tripelennamine
分子式
C16H21N3
化学名
N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine
分子量
Average: 255.358
Monoisotopic: 255.173547687
Monoisotopic: 255.173547687
CAS号
91-81-6
ATC分类
D04A 未知;R06A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem]
生产厂家
- Anabolic inc
- Barr laboratories inc
- Heather drug co inc
- Impax laboratories inc
- Lannett co inc
- Novartis pharmaceuticals corp
- Nylos trading co inc
- Parke davis div warner lambert co
- Watson laboratories inc
封装厂家
- C.O. Truxton Inc.
- Cypress Pharmaceutical Inc.
- Gallipot
- Spectrum Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold. |
| Pharmacodynamics | Used to treat the effects of colds and allergies. Tripelennamine is an antihistamine. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. |
| Mechanism of action | Tripelennamine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. |
| Absorption | Well absorbed in the digestive tract. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Hepatic
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands and trouble in sleeping. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Donepezil | Possible antagonism of action |
| Galantamine | Possible antagonism of action |
食物相互作用
Not Available
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