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药品详细

Trisalicylate-choline(三水杨酸胆碱)

化学结构式图
中文名
三水杨酸胆碱
英文名
Trisalicylate-choline
分子式
C26H29MgNO10
化学名
magnesium(2+) ion (2-hydroxyethyl)trimethylazanium tris(2-hydroxybenzoate)
分子量
Average: 539.814
Monoisotopic: 539.164188051
CAS号
<span class="not-available">Not Available</span>
ATC分类
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%.(PMID: 1728115, 1618240)

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    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
    Pharmacodynamics Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate. Does not affect platelet aggregation.
    Mechanism of action Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination renal
    Half life Not Available
    Clearance Not Available
    Toxicity Salicylate intoxication, known as salicylism, may occur with large doses or extended therapy. Common symptoms of salicylism include headache, dizziness, tinnitus, hearing impairment, confusion, drowsiness, sweating, vomiting, diarrhea, and hyperventilation. A more severe degree of salicylate intoxication can lead to CNS disturbances, alteration in electrolyte balance, respiratory and metabolic acidosis, hyperthermia, and dehydration.
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    logP 1.98 ChemAxon
    pKa (strongest acidic) 2.79 ChemAxon
    pKa (strongest basic) -6.3 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 60.36 ChemAxon
    rotatable bond count 5 ChemAxon
    refractivity 46.13 ChemAxon
    polarizability 12.38 ChemAxon
    药物相互作用
    Drug Interaction
    Betamethasone The corticosteroid, betamethasone, may decrease the effect of the salicylate, trisalicylate-choline.
    Chlorpropamide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, chlorpropamide.
    Fludrocortisone The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
    Gliclazide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, gliclazide.
    Glyburide The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, glibenclamide.
    Hydrocortisone The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
    Methazolamide The salicylate, trisalicylate-choline, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
    Methotrexate The salicylate, trisalicylate-choline, increases the effect and toxicity of methotrexate.
    Minocycline Formation of non-absorbable complexes
    Prednisolone The corticosteroid, prednisolone, may decrease the effect of the salicylate, trisalicylate-choline.
    Prednisone The corticosteroid, prednisone, may decrease the effect of the salicylate, trisalicylate-choline.
    Probenecid The salicylate, trisalicylate-choline, decreases the uricosuric effect of probenecid.
    Tetracycline Formation of non-absorbable complexes
    Triamcinolone The corticosteroid, triamcinolone, may decrease the effect of the salicylate, trisalicylate-choline.
    Warfarin The antiplatelet effects of trisalicylate-choline may increase the bleed risk associated with warfarin.
    食物相互作用
    Not Available

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