药品详细
Tyloxapol(四丁酚醛)
化学结构式图
中文名
四丁酚醛
英文名
Tyloxapol
分子式
Not Available
化学名
分子量
Average:
Monoisotopic:
Monoisotopic:
CAS号
25301-02-4
ATC分类
R05C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Tyloxapol is a non-ionic detergent often used as a surfactant.
生产厂家
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
|
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
药理
| Indication | Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications. |
| Pharmacodynamics | It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. |
| Mechanism of action | Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||
|---|---|---|---|---|
| State | liquid | |||
| Experimental Properties | Not Available | |||
| Predicted Properties |
|
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药物相互作用
食物相互作用
Not Available
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