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药品详细

Tymazoline(Tymazoline)

化学结构式图
中文名
Tymazoline
英文名
Tymazoline
分子式
C14H20N2O
化学名
2-[5-methyl-2-(propan-2-yl)phenoxymethyl]-4,5-dihydro-1H-imidazole
分子量
Average: 232.3214
Monoisotopic: 232.157563272
CAS号
24243-97-8
ATC分类
R01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Tymazoline is a nasal preparation.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Levrier J, Molon-Noblot S, Duval D, Lloyd KG: A new ex vivo method for the study of nasal drops on ciliary function. Fundam Clin Pharmacol. 1989;3(5):471-82. Pubmed
    2. Lorino AM, Lofaso F, Drogou I, Abi-Nader F, Dahan E, Coste A, Lorino H: Effects of different mechanical treatments on nasal resistance assessed by rhinometry. Chest. 1998 Jul;114(1):166-70. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication For the treatment of Inflammation of the lining of the nose and paranasal sinuses and allergic inflammation of nasopharyngeal.
    Pharmacodynamics Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages.
    Mechanism of action Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity A large overdose or accidental oral intake, especially in children, may cause excessive sedation with drowsiness, reduced body temperature, heart rate relief and fluctuations in blood pressure and collapse.
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.18e-01 g/l ALOGPS
    logP 3.2 ALOGPS
    logP 2.64 ChemAxon
    logS -3.3 ALOGPS
    pKa (strongest basic) 7.66 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 33.62 ChemAxon
    rotatable bond count 4 ChemAxon
    refractivity 69.54 ChemAxon
    polarizability 27.29 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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