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药品详细

Tolnaftate(托萘酯)

化学结构式图
中文名
托萘酯
英文名
Tolnaftate
分子式
C19H17NOS
化学名
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
分子量
Average: 307.409
Monoisotopic: 307.103084861
CAS号
2398-96-1
ATC分类
D01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete’s foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. Pubmed
    2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Naphthalenes
    Substructures
    • Naphthalenes
    • Phenols and Derivatives
    • Ethers
    • Benzene and Derivatives
    • Aromatic compounds
    • Anisoles
    • Phenyl Esters
    • Anilines
    适应症
    药理
    Indication Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
    Pharmacodynamics Tolnaftate is a synthetic over-the-counter anti-fungal agent.
    Mechanism of action Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
    Affected organisms
    • Yeast and other fungi
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 111 °C PhysProp
    water solubility 7.02e-05 mg/mL at 25 °C MEYLAN,WM et al. (1996)
    logP 5.1 Not Available
    Predicted Properties
    Property Value Source
    water solubility 5.46e-04 g/l ALOGPS
    logP 4.87 ALOGPS
    logP 5.75 ChemAxon
    logS -5.8 ALOGPS
    pKa (strongest basic) 0.075 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 1 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 12.47 ChemAxon
    rotatable bond count 3 ChemAxon
    refractivity 94.92 ChemAxon
    polarizability 34.22 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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