药品详细
Sulfasalazine(柳氮磺胺吡啶)
化学结构式图
中文名
柳氮磺胺吡啶
英文名
Sulfasalazine
分子式
C18H14N4O5S
化学名
2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid
分子量
Average: 398.393
Monoisotopic: 398.068490268
Monoisotopic: 398.068490268
CAS号
599-79-1
ATC分类
A07E Intestinal Antiinflammatory Agents
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
生产厂家
- Heritage pharmaceuticals inc
- Mutual pharmaceutical co inc
- Pharmacia and upjohn co
- Sandoz inc
- Solvay pharmaceuticals
- Superpharm corp
- Vintage pharmaceuticals inc
- Watson laboratories inc
封装厂家
- Amerisource Health Services Corp.
- A-S Medication Solutions LLC
- Carlisle Laboratories Inc.
- Darby Dental Supply Co. Inc.
- Direct Dispensing Inc.
- Dispensing Solutions
- Greenstone LLC
- Kaiser Foundation Hospital
- Kemwell AB
- Major Pharmaceuticals
- Medisca Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- Mutual Pharmaceutical Co.
- Nucare Pharmaceuticals Inc.
- Patheon Inc.
- PD-Rx Pharmaceuticals Inc.
- Pfizer Inc.
- Pharmacia Inc.
- Pharmedix
- Physicians Total Care Inc.
- Prepak Systems Inc.
- Qualitest
- Remedy Repack
- Tya Pharmaceuticals
- United Research Laboratories Inc.
- Vintage Pharmaceuticals Inc.
- Watson Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent. |
| Pharmacodynamics | Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis. |
| Mechanism of action | The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Sulfasalazine, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown. |
| Absorption | Not Available |
| Volume of distribution |
|
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. |
| Half life | 5-10 hours |
| Clearance |
|
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Azathioprine | Sulfasalazine may increase the toxicity of thiopurine, azathioprine. |
| Azilsartan medoxomil | Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism. |
| Chlorpropamide | Sulfonamide/sulfonylurea: possible hypoglycemia |
| Cyclosporine | The sulfonamide decreases the effect of cyclosporine |
| Digoxin | Sulfasalazine may decrease the effect of digoxin. |
| Mercaptopurine | Sulfasalazine may increase the toxicity of thiopurine, mercaptopurine. |
| Thioguanine | Sulfasalazine may increase the toxicity of thiopurine, thioguanine. |
食物相互作用
- May take Vitamin D.
- Take with a full glass of water No iron, zinc or fluoride within 2 hours of taking this medication.
- Take with food.
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