药品详细
Sulfathiazole(磺胺噻唑)
化学结构式图
中文名
磺胺噻唑
英文名
Sulfathiazole
分子式
C9H9N3O2S2
化学名
4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
分子量
Average: 255.317
Monoisotopic: 255.013617927
Monoisotopic: 255.013617927
CAS号
72-14-0
ATC分类
J01E 未知;D06B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
生产厂家
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
药理
| Indication | Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle. |
| Pharmacodynamics | Not Available |
| Mechanism of action | Not Available |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Metabolism of sulfonamide drugs in animals includes conjugation at the N4-position (acetyl, sulfate, glucuronic acid, and glucose), conjugation at the N1-position (sulfate and glucuronic acid), removal of the p-amino group (formation of the desamino metabolite), ring hydroxylation, and conjugation of the ring hydroxylation products. Dietary nitrite enhances the production of the desamino metabolite of sulfathiazole. The intermediate leading to the desamino metabolite of sulfamethazine is weakly mutagenic in the Ames test (Nelson et al., 1987; Paulson et al., 1987).
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| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Acute oral toxicity (LD50): 4500 mg/kg [Mouse]. |
| Affected organisms | Not Available |
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Methenamine mandelate | Possible crystallization of urates with this combination |
| Methotrexate | The sulfamide increases the toxicity of methotrexate |
食物相互作用
Not Available
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