药品详细

Stanozolol(康力龙)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

康力龙

英文名

Stanozolol

分子式

C₂₁H₃₂N₂O

化学名

2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol

分子量

Average: 328.4916
Monoisotopic: 328.251463656

CAS号

10418-03-8

ATC分类

A14A 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes.

生产厂家

Lundbeck inc

封装厂家

参考

Synthesis Reference

Not Available

General Reference

Guilarte M, Luengo O, Nogueiras C, Labrador-Horrillo M, Munoz E, Lopez A, Cardona V: Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. J Investig Allergol Clin Immunol. 2008;18(2):126-30. Pubmed
Thevis M, Schanzer W: Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators. Handb Exp Pharmacol. 2010;(195):99-126. Pubmed
Sloane DE, Lee CW, Sheffer AL: Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007 Sep;120(3):654-8. Pubmed

剂型

规格

化合物类型

Type	small molecule

Classes

Steroids and Steroid Derivatives

Substructures

Pyrazoles
Hydroxy Compounds
Alcohols and Polyols
Heterocyclic compounds
Aromatic compounds
Imines
Steroids and Steroid Derivatives
Cyclohexenes and Derivatives

适应症

药理

Indication	Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema. Stanozolol can be administered orally or intramuscularly.
Pharmacodynamics	Stanozolol is a synthetic anabolic-androgenic steroid (AAS), which promotes cell growth (anabolism) and development/maintenance of masculine characteristics (androgenism).
Mechanism of action	Stanozolol binds to androgen receptors, such as membrane bound receptor proteins LAGS and stanozolol-binding protein (STBP).
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	24 hours
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Not Available
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
water solubility	1.73e-03 g/l	ALOGPS
logP	4.33	ALOGPS
logP	3.81	ChemAxon
logS	-5.3	ALOGPS
pKa (strongest acidic)	16.23	ChemAxon
pKa (strongest basic)	2.86	ChemAxon
physiological charge	0	ChemAxon
hydrogen acceptor count	2	ChemAxon
hydrogen donor count	2	ChemAxon
polar surface area	48.91	ChemAxon
rotatable bond count	0	ChemAxon
refractivity	96.8	ChemAxon
polarizability	39.29	ChemAxon

药物相互作用

食物相互作用

Not Available

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