用户名： 密   码：
注册 | 忘记密码？
药品详细

Succinylcholine(琥珀酰胆碱)

化学结构式图
中文名
琥珀酰胆碱
英文名
Succinylcholine
分子式
C14H30N2O4
化学名
trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium
分子量
Average: 290.399
Monoisotopic: 290.220557458
CAS号
306-40-1
ATC分类
M03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem]

生产厂家
  • Apothecon inc div bristol myers squibb
  • Hospira inc
  • International medication systems ltd
  • Organon usa inc
  • Sandoz canada inc
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI: Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Carboxylic Acids and Derivatives
  • Quaternary Ammonium Salts
  • Keto-Acids
Substructures
  • Carboxylic Acids and Derivatives
  • Acetates
  • Ethers
  • Quaternary Ammonium Salts
  • Keto-Acids
  • Cations
适应症
药理
Indication Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
Pharmacodynamics Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.
Mechanism of action The mechanism of action of Succinylcholine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
By pseudocholinesterase, to succinylmonocholine and choline.
Route of elimination About 10% of the drug is excreted unchanged in the urine.
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 7.57e-04 g/l ALOGPS
logP -2.5 ALOGPS
logP -8.4 ChemAxon
logS -5.7 ALOGPS
pKa (strongest basic) -6.8 ChemAxon
physiological charge 2 ChemAxon
hydrogen acceptor count 2 ChemAxon
hydrogen donor count 0 ChemAxon
polar surface area 52.6 ChemAxon
rotatable bond count 11 ChemAxon
refractivity 100.94 ChemAxon
polarizability 33.15 ChemAxon
药物相互作用
Drug Interaction
Amikacin The agent increases the effect of muscle relaxant
Clindamycin The agent increases the effect of muscle relaxant
Cyclophosphamide Cyclophosphamide may increase the effect of succinylcholine.
Dihydrocodeine May enhance the bradycardic effect of opioid analgesics. It is recommended to monitor therapy.
Echothiophate Echothiophate iodide may increase the effect of succinylcholine.
Gentamicin The agent increases the effect of muscle relaxant
Lincomycin The agent increases the effect of muscle relaxant
Netilmicin The agent increases the effect of muscle relaxant
Piperacillin The agent increases the effect of the muscle relaxant
Quinidine The quinine derivative increases the effect of the muscle relaxant
Quinine The quinine derivative increases the effect of the muscle relaxant
Tacrine Tacrine may increase the effects of Succinylcholine. Monitor Succinylcholine therapy for increased effects.
Tobramycin The agent increases the effect of the muscle relaxant
食物相互作用
Not Available

返回 | 收藏