药品详细

Sulfadimethoxine(磺胺二甲氧嘧啶)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

磺胺二甲氧嘧啶

英文名

Sulfadimethoxine

分子式

C₁₂H₁₄N₄O₄S

化学名

4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

分子量

Average: 310.329
Monoisotopic: 310.073575646

CAS号

122-11-2

ATC分类

J01E 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

Sulfadimethoxine (trade name Di-Methox, Albon) is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid.

生产厂家

Pfizer inc

封装厂家

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Not Available

Substructures

Not Available

适应症

药理

Indication	For use in the treatment of infections.
Pharmacodynamics	Sulfadimethoxine has been shown to be effective against streptococci, klebsiella, proteus, shigella, staphylococci, escherichia, and salmonella.
Mechanism of action	Not Available
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Not Available
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	203.5 °C	PhysProp
water solubility	343 mg/L	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	1.63	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
water solubility	2.78e-01 g/l	ALOGPS
logP	1.08	ALOGPS
logP	1.26	ChemAxon
logS	-3	ALOGPS
pKa (strongest acidic)	6.91	ChemAxon
pKa (strongest basic)	1.95	ChemAxon
physiological charge	-1	ChemAxon
hydrogen acceptor count	7	ChemAxon
hydrogen donor count	2	ChemAxon
polar surface area	116.43	ChemAxon
rotatable bond count	4	ChemAxon
refractivity	77.75	ChemAxon
polarizability	30.41	ChemAxon

药物相互作用

Drug	Interaction
Methotrexate	The sulfamide increases the toxicity of methotrexate

食物相互作用

Not Available

返回 | 收藏