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药品详细

Selenium Sulfide(硫化硒)

化学结构式图
中文名
硫化硒
英文名
Selenium Sulfide
分子式
SSe
化学名
sulfaneselone
分子量
Average: 111.03
Monoisotopic: 111.888592518
CAS号
7446-34-6
ATC分类
D01A 未知;D11A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.

生产厂家
  • Actavis mid atlantic llc
  • Allergan herbert div allergan inc
  • Chattem inc
  • Ivax pharmaceuticals inc
  • Perrigo new york inc
  • Taro pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. Pubmed
  2. Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.×. Epub 2010 Aug 24. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Inorganic Ions and Gases
Substructures
  • Inorganic Ions and Gases
适应症
药理
Indication For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.
Pharmacodynamics Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
Mechanism of action Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
Absorption There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
Affected organisms
  • Humans and other mammals
  • Fungi
  • Bacteria
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
melting point 100 °C Not Available
water solubility Practically insoluble Not Available
Predicted Properties
Property Value Source
logP 0.53 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 0 ChemAxon
hydrogen donor count 0 ChemAxon
polar surface area 0 ChemAxon
rotatable bond count 0 ChemAxon
refractivity 22.55 ChemAxon
polarizability 5.1 ChemAxon
药物相互作用
Drug Interaction
Eltrombopag Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
食物相互作用
Not Available

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