药品详细
Sevoflurane(七氟醚)
化学结构式图
中文名
七氟醚
英文名
Sevoflurane
分子式
C4H3F7O
化学名
1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane
分子量
Average: 200.0548
Monoisotopic: 200.007212153
Monoisotopic: 200.007212153
CAS号
28523-86-6
ATC分类
N01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia]
生产厂家
- Abbott laboratories
- Baxter healthcare corp
- Halocarbon products corp
- Piramal critical care inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. | ||||||||||||||||
| Pharmacodynamics | Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. | ||||||||||||||||
| Mechanism of action | Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor. | ||||||||||||||||
| Absorption | Rapidly absorbed into circulation via the lungs, however solubility in the blood is low. | ||||||||||||||||
| Volume of distribution | Not Available | ||||||||||||||||
| Protein binding | Not Available | ||||||||||||||||
| Metabolism |
Relatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane.
Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.
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| Route of elimination | The low solubility of sevoflurane facilitates rapid elimination via the lungs. In vivo metabolism studies suggest that approximately 5% of the sevoflurane dose may be metabolized. Up to 3.5% of the sevoflurane dose appears in the urine as inorganic fluoride. | ||||||||||||||||
| Half life | 15-23 hours | ||||||||||||||||
| Clearance | Not Available | ||||||||||||||||
| Toxicity | LC50=49881 ppm/hr (rat), LD50=10.8 g/kg (rat) | ||||||||||||||||
| Affected organisms |
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| Pathways | Not Available | ||||||||||||||||
理化性质
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| State | liquid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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