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药品详细

Sodium lauryl sulfate(月桂基硫酸钠)

化学结构式图
中文名
月桂基硫酸钠
英文名
Sodium lauryl sulfate
分子式
C12H25NaO4S
化学名
sodium dodecyl sulfate
分子量
Average: 288.379
Monoisotopic: 288.137124653
CAS号
151-21-3
ATC分类
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.

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    参考
    Synthesis Reference Not Available
    General Reference
    1. Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. Pubmed
    2. Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. Pubmed
    3. Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. Pubmed
    4. Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. Pubmed
    5. Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. Pubmed
    6. Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
    Pharmacodynamics SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.
    Mechanism of action Like other surfactants, SLS is amphiphilic. It thus migrates to the surface of liquids, where its alignment and aggregation with other SLS molecules lowers the surface tension. This allows for easier spreading and mixing of the liquid. SLS has potent protein denaturing activity and inhibits the infectivity of viruses by by solubilizing the viral envelope and/or by denaturing envelope and/or capsid proteins.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Oral (LD50): Acute: 1288 mg/kg [Rat]
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 205.5 °C PhysProp
    water solubility 1E+005 mg/L SINGER,MM & TJEERDEMA,RS (1993)
    logP 1.60 HANSCH,C ET AL. (1995)
    Predicted Properties
    Property Value Source
    water solubility 1.21e-02 g/l ALOGPS
    logP 3.86 ALOGPS
    logP 4.42 ChemAxon
    logS -4.4 ALOGPS
    pKa (strongest acidic) -1.5 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 66.43 ChemAxon
    rotatable bond count 12 ChemAxon
    refractivity 67.81 ChemAxon
    polarizability 31.17 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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