药品详细
Sodium Tetradecyl Sulfate(十四烷基硫酸钠)
化学结构式图
中文名
十四烷基硫酸钠
英文名
Sodium Tetradecyl Sulfate
分子式
C14H30O4S
化学名
(tetradecyloxy)sulfonic acid
分子量
Average: 294.451
Monoisotopic: 294.186480138
Monoisotopic: 294.186480138
CAS号
1191-50-0
ATC分类
C05B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
生产厂家
- Bioniche pharma usa llc
- Elkins sinn div ah robins co inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. |
| Pharmacodynamics | Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent. |
| Mechanism of action | Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat) |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties | Not Available | |||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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