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药品详细

Riboflavin(核黄素)

化学结构式图
中文名
核黄素
英文名
Riboflavin
分子式
C17H20N4O6
化学名
7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
分子量
Average: 376.3639
Monoisotopic: 376.138284392
CAS号
83-88-5
ATC分类
A11H 未知
药物类型
small molecule
阶段
approved, nutraceutical
商品名
同义名
基本介绍

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Isoalloxazines
    Substructures
    • Pterins
    • Glycerol and Derivatives
    • Hydroxy Compounds
    • Isoalloxazines
    • Benzene and Derivatives
    • Alcohols and Polyols
    • Pyrimidines and Derivatives
    • Pyrazines
    • Heterocyclic compounds
    • Aromatic compounds
    • Pteridines
    • Cyanamides
    • Quinoxalines
    适应症
    药理
    Indication For the treatment of ariboflavinosis (vitamin B2 deficiency).
    Pharmacodynamics Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
    Mechanism of action Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
    Absorption Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
    Volume of distribution Not Available
    Protein binding 60%
    Metabolism
    Hepatic.
    Route of elimination Not Available
    Half life 66-84 minutes
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 280 dec °C PhysProp
    water solubility 84.7 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
    logP -1.46 HANSCH,C ET AL. (1995)
    logS -3.68 ADME Research, USCD
    pKa 10.2 BUDAVARI,S ET AL. (1996)
    Predicted Properties
    Property Value Source
    water solubility 6.57e-01 g/l ALOGPS
    logP -1.1 ALOGPS
    logP -0.92 ChemAxon
    logS -2.8 ALOGPS
    pKa (strongest acidic) 6.97 ChemAxon
    pKa (strongest basic) 0.76 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 9 ChemAxon
    hydrogen donor count 5 ChemAxon
    polar surface area 155.05 ChemAxon
    rotatable bond count 5 ChemAxon
    refractivity 96.27 ChemAxon
    polarizability 37.5 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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