药品详细

Ritodrine(利托君)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

利托君

英文名

Ritodrine

分子式

C₁₇H₂₁NO₃

化学名

4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol

分子量

Average: 287.3535
Monoisotopic: 287.152143543

CAS号

26652-09-5

ATC分类

G02C 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

Adrenergic beta-agonist used to control premature labor. [PubChem]

生产厂家

Abraxis pharmaceutical products
Astrazeneca lp
Hospira inc

封装厂家

Solvay Pharmaceuticals

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Phenethylamines
Amphetamines

Substructures

Hydroxy Compounds
Benzyl Alcohols and Derivatives
Aliphatic and Aryl Amines
Phenols and Derivatives
Benzene and Derivatives
Amino Alcohols
Phenethylamines
Aromatic compounds
Alcohols and Polyols
Phenyl Esters
Amphetamines

适应症

药理

Indication	For the treatment and prophylaxis of premature labour
Pharmacodynamics	Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
Mechanism of action	Ritodrine is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	~56%
Metabolism	Hepatic, by both the mother and fetus
Route of elimination	Not Available
Half life	1.7-2.6 hours
Clearance	Not Available
Toxicity	LD₅₀=64mg/kg (mice, IV); LD₅₀=540 mg/kg (mice, oral); LD₅₀=85 mg/kg (rat, IV)
Affected organisms	Humans and other mammals
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	88-90 °C	Not Available
water solubility	Complete	Not Available
logP	2.4	Not Available

Predicted Properties

Property	Value	Source
water solubility	1.79e-01 g/l	ALOGPS
logP	1.53	ALOGPS
logP	1.82	ChemAxon
logS	-3.2	ALOGPS
pKa (strongest acidic)	9.15	ChemAxon
pKa (strongest basic)	9.81	ChemAxon
physiological charge	1	ChemAxon
hydrogen acceptor count	4	ChemAxon
hydrogen donor count	4	ChemAxon
polar surface area	72.72	ChemAxon
rotatable bond count	6	ChemAxon
refractivity	83.02	ChemAxon
polarizability	31.56	ChemAxon

药物相互作用

食物相互作用

Not Available

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