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药品详细

Rosoxacin(Rosoxacin)

化学结构式图
中文名
Rosoxacin
英文名
Rosoxacin
分子式
C17H14N2O3
化学名
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
分子量
Average: 294.3047
Monoisotopic: 294.100442324
CAS号
40034-42-2
ATC分类
J01M 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • (Iso)quinolines and Derivatives
    • Fluoroquinolones and Quinolones
    Substructures
    • Hydroxy Compounds
    • Acetates
    • Pyridines and Derivatives
    • Benzene and Derivatives
    • Carboxylic Acids and Derivatives
    • Heterocyclic compounds
    • Aromatic compounds
    • (Iso)quinolines and Derivatives
    • Fluoroquinolones and Quinolones
    适应症
    药理
    Indication For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
    Pharmacodynamics Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
    Mechanism of action Rosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Enteric bacteria and other eubacteria
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 290 °C PhysProp
    water solubility 0.0209 mg/mL at 25 °C MEYLAN,WM et al. (1996)
    logP 3 Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.02e-01 g/l ALOGPS
    logP 1.85 ALOGPS
    logP 1.9 ChemAxon
    logS -3.5 ALOGPS
    pKa (strongest acidic) 6.18 ChemAxon
    pKa (strongest basic) 4.9 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 5 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 70.5 ChemAxon
    rotatable bond count 3 ChemAxon
    refractivity 83.06 ChemAxon
    polarizability 30.8 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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