药品详细

Procaterol(丙卡特罗)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

丙卡特罗

英文名

Procaterol

分子式

C₁₆H₂₂N₂O₃

化学名

8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(propan-2-yl)amino]butyl]-1,2-dihydroquinolin-2-one

分子量

Average: 290.3575
Monoisotopic: 290.16304258

CAS号

72332-33-3

ATC分类

R03C 未知;R03A 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation. [PubChem]

生产厂家

封装厂家

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Hydroxyquinolines
Quinolinones
Fluoroquinolones and Quinolones

Substructures

Hydroxy Compounds
Benzyl Alcohols and Derivatives
Aliphatic and Aryl Amines
Phenols and Derivatives
Pyridines and Derivatives
Benzene and Derivatives
Hydroxyquinolines
Amino Alcohols
Phenethylamines
Pyridines
Heterocyclic compounds
Aromatic compounds
Quinolinones
(Iso)quinolines and Derivatives
Alcohols and Polyols
Phenyl Esters
Amphetamines
Fluoroquinolones and Quinolones

适应症

药理

Indication	For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Pharmacodynamics	Procaterol is a long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.
Mechanism of action	Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Absorption	Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses.
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor.
Affected organisms	Humans and other mammals
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
water solubility	3.29e-01 g/l	ALOGPS
logP	1.28	ALOGPS
logP	0.88	ChemAxon
logS	-3	ALOGPS
pKa (strongest acidic)	8.52	ChemAxon
pKa (strongest basic)	9.88	ChemAxon
physiological charge	1	ChemAxon
hydrogen acceptor count	4	ChemAxon
hydrogen donor count	4	ChemAxon
polar surface area	81.59	ChemAxon
rotatable bond count	5	ChemAxon
refractivity	84.58	ChemAxon
polarizability	31.69	ChemAxon

药物相互作用

Drug	Interaction
Amitriptyline	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of procaterol.
Amoxapine	The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of procaterol.
Atenolol	Antagonism
Bisoprolol	Antagonism
Carvedilol	Antagonism
Clomipramine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of procaterol.
Desipramine	The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of procaterol.
Doxepin	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of procaterol.
Esmolol	Antagonism
Imipramine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of procaterol.
Isocarboxazid	Increased arterial pressure
Labetalol	Antagonism
Linezolid	Possible increase of arterial pressure
Methyldopa	Increased arterial pressure
Metoprolol	Antagonism
Midodrine	Increased arterial pressure
Moclobemide	Moclobemide increases the sympathomimetic effect of procaterol.
Nadolol	Antagonism
Nortriptyline	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of procaterol.
Phenelzine	Increased arterial pressure
Pindolol	Antagonism
Propranolol	Antagonism
Rasagiline	Increased arterial pressure
Reserpine	Increased arterial pressure
Timolol	Antagonism

食物相互作用

Not Available

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