药品详细
Propantheline(普鲁)
化学结构式图
中文名
普鲁
英文名
Propantheline
分子式
C23H30NO3
化学名
methylbis(propan-2-yl){2-[(9H-xanthen-9-yl)carbonyloxy]ethyl}azanium
分子量
Average: 368.4892
Monoisotopic: 368.222568831
Monoisotopic: 368.222568831
CAS号
298-50-0
ATC分类
A03A Drugs for Functional Bowel Disorders
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. [PubChem]
生产厂家
- Ascot hosp pharmaceuticals inc div travenol laboratories inc
- Gd searle llc
- Heather drug co inc
- Impax laboratories inc
- Mylan pharmaceuticals inc
- Par pharmaceutical inc
- Private formulations inc
- Roxane laboratories inc
- Sandoz inc
- Shire development inc
- Tablicaps inc
- Watson laboratories inc
封装厂家
- Dispensing Solutions
- Gallipot
- Kaiser Foundation Hospital
- Major Pharmaceuticals
- Roxane Labs
- Shire Inc.
- Southwood Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
药理
| Indication | For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder. |
| Pharmacodynamics | Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. |
| Mechanism of action | Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Approximately 70% of the dose is excreted in the urine, mostly as metabolites. |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Donepezil | Possible antagonism of action |
| Galantamine | Possible antagonism of action |
| Haloperidol | The anticholinergic increases the risk of psychosis and tardive dyskinesia |
| Tacrine | The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Propantheline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents. |
| Trimethobenzamide | Trimethobenzamide and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects. |
| Triprolidine | Triprolidine and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects. |
| Trospium | Trospium and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects. |
食物相互作用
Not Available
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