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药品详细

Pyridoxal(吡哆醛)

化学结构式图
中文名
吡哆醛
英文名
Pyridoxal
分子式
C8H9NO3
化学名
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
分子量
Average: 167.162
Monoisotopic: 167.058243159
CAS号
65-22-5
ATC分类
A11H 未知;C10A 未知
药物类型
small molecule
阶段
approved, nutraceutical
商品名
同义名
基本介绍

The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Pyridoxals and Derivatives
    Substructures
    • Pyridoxals and Derivatives
    • Hydroxy Compounds
    • Pyridines and Derivatives
    • Aldehydes
    • Alcohols and Polyols
    • Heterocyclic compounds
    • Aromatic compounds
    • Imines
    • Phenols and Derivatives
    适应症
    药理
    Indication Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances.
    Pharmacodynamics Pyridoxal principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
    Mechanism of action Pyridoxal is the precursor to pyridoxal phosphate. Pyridoxal 5'-phosphate is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Oral LD50 Rat: 2150 mg/kg, Oral LD50 Mouse: 1800 mg/kg
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 165 °C PhysProp
    water solubility 5E+005 mg/L COFFEN,DL (1978)
    logP 0 Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.17e+01 g/l ALOGPS
    logP 0.02 ALOGPS
    logP 0.18 ChemAxon
    logS -1.2 ALOGPS
    pKa (strongest acidic) 7.97 ChemAxon
    pKa (strongest basic) 4.11 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 4 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 70.42 ChemAxon
    rotatable bond count 2 ChemAxon
    refractivity 43.87 ChemAxon
    polarizability 16.28 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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