药品详细
Polystyrene sulfonate(聚苯乙烯磺酸盐)
化学结构式图
中文名
聚苯乙烯磺酸盐
英文名
Polystyrene sulfonate
分子式
Not Available
化学名
分子量
Average:
Monoisotopic:
Monoisotopic:
CAS号
28210-41-5
ATC分类
V03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV. [Wikipedia]
生产厂家
- Carolina medical products co
- Citrusphrma llc
- Kvk tech inc
- Morton grove pharmaceuticals inc
- Paddock laboratories inc
- Roxane laboratories inc
- Sanofi aventis us llc
- Wockhardt eu operations (swiss) ag
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
药理
| Indication | Used to treat abnormally high potassium levels. |
| Pharmacodynamics | Polystyrene sulfonate affects the exchange of sodium and potassium in the body. Polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. It is a potassium-binding ion-exchange resin that can be administered orally (25 grams in 20% sorbitol) or rectally (50 grams in 20% sorbitol). |
| Mechanism of action | Polystyrene sulfonate, which is not absorbed, binds excess potassium, carrying it out of the body. The indigestible potassium polystryene sulfonate complex is excreted with the faeces, preventing the absorption of potassium into the blood stream. Hence, the serum potassium level decreases. |
| Absorption | Not absorbed following oral administration. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
none
|
| Route of elimination | Feces. |
| Half life | none |
| Clearance | Not Available |
| Toxicity | Overdose symptoms may include confusion, irritability, trouble thinking or concentrating, muscle weakness, or trouble breathing. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||
|---|---|---|---|---|
| State | solid | |||
| Experimental Properties | Not Available | |||
| Predicted Properties |
|
|||
药物相互作用
| Drug | Interaction |
|---|---|
| Aluminium | Risk of alkalosis in renal impairment |
| Amiloride | Risk of alkalosis in renal impairment |
| Calcium | Formation of non-absorbable complexes |
| Eplerenone | Risk of alkalosis in renal impairment |
| Magnesium | Risk of alkalosis in renal impairment |
| Potassium | Risk of alkalosis in renal impairment |
| Spironolactone | Risk of alkalosis in renal impairment |
| Triamterene | Antagonism of action |
食物相互作用
- Avoid calcium, magnesium and potassium.
- Take on an empty stomach.
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