药品详细
Polythiazide(噻)
化学结构式图
中文名
噻
英文名
Polythiazide
分子式
C11H13ClF3N3O4S3
化学名
6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
分子量
Average: 439.882
Monoisotopic: 438.970880311
Monoisotopic: 438.970880311
CAS号
346-18-9
ATC分类
C03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
生产厂家
- Pfizer inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
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适应症
药理
| Indication | Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure. | ||||||
| Pharmacodynamics | As a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine, as water normally follows solutes. More frequent urination is due to the increased loss of water that has not been retained from the body as a result of a concomitant relationship with sodium loss from the convoluted tubule. The short-term anti-hypertensive action is based on the fact that thiazides decrease preload, decreasing blood pressure | ||||||
| Mechanism of action | As a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. | ||||||
| Absorption | Not Available | ||||||
| Volume of distribution | Not Available | ||||||
| Protein binding | Not Available | ||||||
| Metabolism |
Not Available
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| Route of elimination | Not Available | ||||||
| Half life | Not Available | ||||||
| Clearance | Not Available | ||||||
| Toxicity | Not Available | ||||||
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理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Digoxin | Possible electrolyte variations and arrhythmias |
| Lithium | The thiazide diuretic, polythiazide, may increase serum levels of lithium. |
| Trandolapril | The thiazide diuretic, Polythiazide, may increase the hypotensive effect of Trandolapril. Polythiazide may also increase the nephrotoxicity of Trandolapril. Monitor for postural hypotension at initiation of concomitant therapy and renal dysfunction during chronic therapy. |
| Treprostinil | Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use. |
食物相互作用
Not Available
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