药品详细
Practolol(心得宁)
化学结构式图
中文名
心得宁
英文名
Practolol
分子式
C14H22N2O3
化学名
N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
分子量
Average: 266.3361
Monoisotopic: 266.16304258
Monoisotopic: 266.16304258
CAS号
6673-35-4
ATC分类
C07A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. [PubChem]
生产厂家
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
药理
| Indication | Used in the emergency treatment of cardiac arrhythmias. |
| Pharmacodynamics | Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias. Beta blockers inhibit normal epinephrine-mediated sympathetic actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement/physical exertion on heart rate and force of contraction and dilation of blood vessels. |
| Mechanism of action | Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing. |
| Affected organisms | Not Available |
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Acetohexamide | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Chlorpropamide | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Clonidine | Increased hypertension when clonidine stopped |
| Dihydroergotamine | Ischemia with risk of gangrene |
| Disopyramide | The beta-blocker, practolol, may increase the toxicity of disopyramide. |
| Epinephrine | Hypertension, then bradycardia |
| Ergotamine | Ischemia with risk of gangrene |
| Fenoterol | Antagonism |
| Formoterol | Antagonism |
| Gliclazide | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Glyburide | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Ibuprofen | Risk of inhibition of renal prostaglandins |
| Indomethacin | Risk of inhibition of renal prostaglandins |
| Insulin Glargine | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Methysergide | Ischemia with risk of gangrene |
| Orciprenaline | Antagonism |
| Oxprenolol | Antagonism |
| Pipobroman | Antagonism |
| Piroxicam | Risk of inhibition of renal prostaglandins |
| Prazosin | Risk of hypotension at the beginning of therapy |
| Repaglinide | The beta-blocker, practolol, may decrease symptoms of hypoglycemia. |
| Terbutaline | Antagonism |
食物相互作用
- Avoid alcohol.
- Avoid natural licorice.
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