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药品详细

Pranlukast(普仑司特)

化学结构式图
中文名
普仑司特
英文名
Pranlukast
分子式
C27H23N5O4
化学名
N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide
分子量
Average: 481.5026
Monoisotopic: 481.175004249
CAS号
103177-37-3
ATC分类
R03D 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Chromones
    Substructures
    • Phenols and Derivatives
    • Amino Ketones
    • Ethers
    • Benzene and Derivatives
    • Carboxylic Acids and Derivatives
    • Chromones
    • Tetrazoles
    • Heterocyclic compounds
    • Aromatic compounds
    • Anisoles
    • Carboxamides and Derivatives
    • Imines
    • Benzoyl Derivatives
    • Cyanamides
    • Phenyl Esters
    • Benzamides
    • Anilines
    适应症
    药理
    Indication Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
    Pharmacodynamics Pranlukast is a cysteinyl leukotriene receptor-1 antagonist.
    Mechanism of action Pranlukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Pranlukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Hepatic
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 3.00e-03 g/l ALOGPS
    logP 4.84 ALOGPS
    logP 4.67 ChemAxon
    logS -5.2 ALOGPS
    pKa (strongest acidic) 5.96 ChemAxon
    pKa (strongest basic) -2.2 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 7 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 119.09 ChemAxon
    rotatable bond count 9 ChemAxon
    refractivity 139.15 ChemAxon
    polarizability 49.7 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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