药品详细

Pentosan Polysulfate(多硫酸戊聚糖)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

多硫酸戊聚糖

英文名

Pentosan Polysulfate

分子式

C₁₀H₁₈O₂₁S₄

化学名

[(2S,3R,4S,5R)-5-hydroxy-2-{[(3R,4S,5R,6R)-6-hydroxy-4,5-bis(sulfooxy)oxan-3-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic acid

分子量

Average: 602.497
Monoisotopic: 601.922340398

CAS号

37300-21-3

ATC分类

C05B 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

A sulfated pentosyl polysaccharide with heparin-like properties. [PubChem]

生产厂家

Ortho mcneil janssen pharmaceuticals inc

封装厂家

Alza Corp.
A-S Medication Solutions LLC
Ivax Pharmaceuticals
Janssen-Ortho Inc.
McNeil Laboratories
Murfreesboro Pharmaceutical Nursing Supply
Ortho Mcneil Janssen Pharmaceutical Inc.
Physicians Total Care Inc.

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Carbohydrates

Substructures

Carbohydrates
Glycerol and Derivatives
Hydroxy Compounds
Pyrans
Acetals and Derivatives
Sulfuric Acids and Derivatives
Sulfonyls
Ethers
Sulfate Esters
Heterocyclic compounds
Alcohols and Polyols

适应症

药理

Indication	For the relief of bladder pain or discomfort associated with interstitial cystitis.
Pharmacodynamics	Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.
Mechanism of action	Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Absorption	Slow
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	4.8 hours
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
logP	-8	Not Available

Predicted Properties

Property	Value	Source
water solubility	3.49e+00 g/l	ALOGPS
logP	-2.5	ALOGPS
logP	-11	ChemAxon
logS	-2.2	ALOGPS
pKa (strongest acidic)	-2.9	ChemAxon
pKa (strongest basic)	-3.6	ChemAxon
physiological charge	-4	ChemAxon
hydrogen acceptor count	17	ChemAxon
hydrogen donor count	6	ChemAxon
polar surface area	322.55	ChemAxon
rotatable bond count	10	ChemAxon
refractivity	96.38	ChemAxon
polarizability	46.17	ChemAxon

药物相互作用

食物相互作用

Take on an empty stomach, 1 hour before or 2 hours after meals.

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