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药品详细

Phenindamine(苯茚胺)

化学结构式图
中文名
苯茚胺
英文名
Phenindamine
分子式
C19H19N
化学名
2-methyl-9-phenyl-1H,2H,3H,4H,9H-indeno[2,1-c]pyridine
分子量
Average: 261.3609
Monoisotopic: 261.151749613
CAS号
82-88-2
ATC分类
R06A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.

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    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Phenylpropenes
    • Phenylpropylamines
    • Indenes and Derivatives
    Substructures
    • Alkanes and Alkenes
    • Phenylpropenes
    • Benzene and Derivatives
    • Cyclopentadienes
    • Aliphatic and Aryl Amines
    • Isoprenes
    • Heterocyclic compounds
    • Aromatic compounds
    • Phenylpropylamines
    • Indenes and Derivatives
    适应症
    药理
    Indication Used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
    Pharmacodynamics Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
    Mechanism of action Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 91 °C PhysProp
    Predicted Properties
    Property Value Source
    water solubility 2.77e-02 g/l ALOGPS
    logP 4.04 ALOGPS
    logP 3.62 ChemAxon
    logS -4 ALOGPS
    pKa (strongest acidic) 18.01 ChemAxon
    pKa (strongest basic) 9 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 1 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 3.24 ChemAxon
    rotatable bond count 1 ChemAxon
    refractivity 85.03 ChemAxon
    polarizability 31.13 ChemAxon
    药物相互作用
    Drug Interaction
    Donepezil Possible antagonism of action
    Galantamine Possible antagonism of action
    Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Phenindamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
    Trimethobenzamide Trimethobenzamide and Phenindamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
    Triprolidine Triprolidine and Phenindamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
    Trospium Trospium and Phenindamine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
    食物相互作用
    • Avoid alcohol.
    • Take with food to reduce irritation.

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