药品详细
Phenindione(苯茚二酮)
化学结构式图
中文名
苯茚二酮
英文名
Phenindione
分子式
C15H10O2
化学名
2-phenyl-2,3-dihydro-1H-indene-1,3-dione
分子量
Average: 222.2387
Monoisotopic: 222.068079564
Monoisotopic: 222.068079564
CAS号
83-12-5
ATC分类
B01A 抗血栓药
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
生产厂家
- Sanofi aventis us llc
封装厂家
参考
Synthesis Reference | Not Available |
General Reference |
剂型
规格
化合物类型
Type | small molecule |
Classes |
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Substructures |
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适应症
药理
Indication | For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis. |
Pharmacodynamics | Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects. |
Mechanism of action | Phenindione inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. |
Absorption | Absorbed slowly from the gastrointestinal tract. |
Volume of distribution | Not Available |
Protein binding | 88% |
Metabolism |
Hepatic.
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Route of elimination | Not Available |
Half life | 5-10 hours |
Clearance | Not Available |
Toxicity | Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg. |
Affected organisms |
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Pathways | Not Available |
理化性质
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State | solid | ||||||||||||||||||||||||||||||||||||||||||
Experimental Properties |
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Predicted Properties |
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药物相互作用
食物相互作用
Not Available