| Indication |
Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity. |
| Pharmacodynamics |
Not Available |
| Mechanism of action |
Phenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes. |
| Absorption |
Phenol is rapidly absorbed through the skin and into the lungs. |
| Volume of distribution |
At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms. |
| Protein binding |
Not Available |
| Metabolism |
Phenyl sulfate, phenyl glucuronide, quinol sulfate, and quinol glucuronide were detected in human beings as phenol metabolites.
|
| Route of elimination |
The kidney is the primary route of elimination of phenol. |
| Half life |
Not Available |
| Clearance |
In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled. |
| Toxicity |
Mouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905).
Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944).
Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944).
Rat, Oral, LD50: 0.65. (Flickinger, 1976).
Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970).
|
| Affected organisms |
|
| Pathways |
Not Available |
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