药品详细
Phytonadione(植物甲萘醌)
化学结构式图
中文名
植物甲萘醌
英文名
Phytonadione
分子式
C31H46O2
化学名
2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione
分子量
Average: 450.6957
Monoisotopic: 450.349780716
Monoisotopic: 450.349780716
CAS号
84-80-0
ATC分类
B02B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Phytonadione is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
生产厂家
- Aton pharma inc
- Eli lilly and co
- Glaxosmithkline
- Hoffmann la roche inc
- Hospira inc
- International medication system
封装厂家
- Amphastar Pharmaceuticals
- Apotheca Inc.
- Aton Pharma Inc.
- Baxter International Inc.
- Bimeda Inc.
- Cardinal Health
- Comprehensive Consultant Services Inc.
- Draxis Specialty Pharmaceuticals Inc.
- Gallipot
- General Injectables and Vaccines Inc.
- GRB SRL
- H.J. Harkins Co. Inc.
- Hospira Inc.
- Kaiser Foundation Hospital
- Merck & Co.
- Murfreesboro Pharmaceutical Nursing Supply
- Neuman Distributors Inc.
- PD-Rx Pharmaceuticals Inc.
- Physicians Total Care Inc.
- Professional Co.
- Rebel Distributors Corp.
- Remedy Repack
- Resource Optimization and Innovation LLC
- Sandoz
- Southwood Pharmaceuticals
- Spectrum Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
药理
| Indication | For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia |
| Pharmacodynamics | Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). |
| Mechanism of action | Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phytonadione results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria. |
| Absorption | Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Almost no free unmetabolized vitamin K appears in bile or urine. |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | The intravenous LD50 of phytonadione in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | liquid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Warfarin | Phytonadione (vitamin K) may antagonize the anticoagulant effects of warfarin. Monitor for changes in prothrombin time if phytonadione intake (either via supplements or vitamin K-rich foods) is increased or decreased. |
食物相互作用
Not Available
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