用户名： 密   码：
注册 | 忘记密码？
药品详细

Polidocanol(聚多卡醇)

化学结构式图
中文名
聚多卡醇
英文名
Polidocanol
分子式
C14H30O2
化学名
2-(dodecyloxy)ethan-1-ol
分子量
Average: 230.3868
Monoisotopic: 230.224580204
CAS号
9002-92-0
ATC分类
C05B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I: Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg. 2012 Aug;38(8):1322-30. doi: 10.1111/j.1524-4725.2012.02422.×. Epub 2012 May 23. Pubmed
    2. Weiss RA, Voigts R, Howell DJ: Absence of Concentration Congruity in Six Compounded Polidocanol Samples Obtained for Leg Sclerotherapy. Dermatol Surg. 2011 Mar 17. doi: 10.1111/j.1524-4725.2011.01906.×. Pubmed
    3. http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_113.pdf
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity.
    Pharmacodynamics Polidocanol has a concentration and volume dependent damaging effect on the blood vessel endothelium.
    Mechanism of action When administered, Polidocanol locally damages blood vessel endothelium. Following the endothelial damage, platelets aggregate at the site and attach to the venous wall eventually resulting in a dense network of platelets, cellular debris, and fibrin that occludes the vessel. Eventually the vessel is replaced by connective fibrous tissue.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life ~1.5 h.
    Clearance Not Available
    Toxicity Not Available
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State liquid
    Experimental Properties
    Property Value Source
    melting point 33-36 °C Not Available
    boiling point 615.857 °C at 760 mmHg Not Available
    water solubility miscible http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_113.pdf
    logP 3.94 # http://www.chemicalize.org/structure/#!mol=polidocanol
    Predicted Properties
    Property Value Source
    water solubility 1.86e-03 g/l ALOGPS
    logP 5.15 ALOGPS
    logP 4.31 ChemAxon
    logS -5.1 ALOGPS
    pKa (strongest acidic) 15.12 ChemAxon
    pKa (strongest basic) -2.7 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 2 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 29.46 ChemAxon
    rotatable bond count 13 ChemAxon
    refractivity 69.99 ChemAxon
    polarizability 31.24 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

    返回 | 收藏