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药品详细

Oxandrolone(氧甲氢龙)

化学结构式图
中文名
氧甲氢龙
英文名
Oxandrolone
分子式
C19H30O3
化学名
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
分子量
Average: 306.4397
Monoisotopic: 306.219494826
CAS号
53-39-4
ATC分类
A14A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

A synthetic hormone with anabolic and androgenic properties. [PubChem]

生产厂家
  • Par pharmaceutical inc
  • Roxane laboratories inc
  • Sandoz inc
  • Savient pharmaceuticals inc
  • Upsher smith laboratories inc
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Demling RH, DeSanti L: Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec;29(8):793-7. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Steroids and Steroid Derivatives
Substructures
  • Steroids and Steroid Derivatives
  • Carboxylic Acids and Derivatives
  • Hydroxy Compounds
  • Pyrans
  • Acetates
  • Lactones
  • Ethers
  • Alcohols and Polyols
  • Heterocyclic compounds
适应症
药理
Indication Use to promote weight gain after weight loss following extensive surgery.
Pharmacodynamics Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.
Mechanism of action Oxandrolones interact with androgen receptors in target tissues.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Renal
Route of elimination Not Available
Half life 0.55 hours (1st phage), 9 hours (2nd phase)
Clearance Not Available
Toxicity The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg.
Affected organisms
  • Humans and other mammals
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
melting point 236.5 °C PhysProp
logP 4.2 Not Available
Predicted Properties
Property Value Source
water solubility 1.40e-02 g/l ALOGPS
logP 3.36 ALOGPS
logP 2.95 ChemAxon
logS -4.3 ALOGPS
pKa (strongest basic) -0.53 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 2 ChemAxon
hydrogen donor count 1 ChemAxon
polar surface area 46.53 ChemAxon
rotatable bond count 0 ChemAxon
refractivity 84.75 ChemAxon
polarizability 35.29 ChemAxon
药物相互作用
Drug Interaction
Warfarin Oxandrolone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if oxandrolone is initiated, discontinued or dose changed.
食物相互作用
Not Available

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