药品详细

Oxyphencyclimine(Oxyphencyclimine)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

Oxyphencyclimine

英文名

Oxyphencyclimine

分子式

C₂₀H₂₈N₂O₃

化学名

(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

分子量

Average: 344.4479
Monoisotopic: 344.209992772

CAS号

125-53-1

ATC分类

A03A Drugs for Functional Bowel Disorders

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.

生产厂家

Pfizer laboratories div pfizer inc

封装厂家

Professional Co.

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Phenylacetates

Substructures

Carboxylic Acids and Derivatives
Hydroxy Compounds
Benzyl Alcohols and Derivatives
Acetates
Phenylacetates
Short-chain Hydroxy Acids
Ethers
Benzene and Derivatives
Pyrimidines and Derivatives
Alcohols and Polyols
Heterocyclic compounds
Aromatic compounds
Carboxamidines
Imines

适应症

药理

Indication	For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
Pharmacodynamics	Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
Mechanism of action	Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
water solubility	6.61 mg/L at 25 °C	Not Available
logP	3.7	Not Available

Predicted Properties

Property	Value	Source
water solubility	5.67e-02 g/l	ALOGPS
logP	2.89	ALOGPS
logP	2.62	ChemAxon
logS	-3.8	ALOGPS
pKa (strongest acidic)	11.53	ChemAxon
pKa (strongest basic)	8.37	ChemAxon
physiological charge	1	ChemAxon
hydrogen acceptor count	4	ChemAxon
hydrogen donor count	1	ChemAxon
polar surface area	62.13	ChemAxon
rotatable bond count	6	ChemAxon
refractivity	97.13	ChemAxon
polarizability	38.34	ChemAxon

药物相互作用

Drug	Interaction
Haloperidol	The anticholinergic increases the risk of psychosis and tardive dyskinesia

食物相互作用

Not Available

返回 | 收藏