药品详细
Pancuronium(泮库溴铵)
化学结构式图
中文名
泮库溴铵
英文名
Pancuronium
分子式
C35H60N2O4
化学名
1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(1-methylpiperidin-1-ium-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium
分子量
Average: 572.8619
Monoisotopic: 572.455308418
Monoisotopic: 572.455308418
CAS号
15500-66-0
ATC分类
M03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
生产厂家
- Astrazeneca lp
- Elkins sinn div ah robins co inc
- Hospira inc
- Organon usa inc
- Teva parenteral medicines inc
封装厂家
- Baxter International Inc.
- Elkins-Sinn Inc.
- Hospira Inc.
- Teva Pharmaceutical Industries Ltd.
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used as a muscle relaxant during anesthesia and surgical procedures. |
| Pharmacodynamics | Pancuronium is a typical non-depolarising curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is, unlike suxamethonium, a non-depolarising agent, which means, that it causes no spontaneous depolarisations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Pancuronium has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e., blocking ganglions) activity. |
| Mechanism of action | Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents. |
| Absorption | Not Available |
| Volume of distribution |
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| Protein binding | 77 to 91% |
| Metabolism |
Hepatic.
|
| Route of elimination | Not Available |
| Half life | 1.5 to 2.7 hours. |
| Clearance |
|
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Amikacin | The agent increases the effect of muscle relaxant |
| Aminophylline | Theophylline decreases the effect of muscle relaxant |
| Azathioprine | The agent decreases the effect of the muscle relaxant |
| Carbamazepine | Decreases the effect of muscle relaxant |
| Clindamycin | The agent increases the effect of muscle relaxant |
| Colistimethate | Colistimethate may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. If possible, avoid concomitant use of these products. Monitor for deeper, prolonged neuromuscular-blocking effects (respiratory paralysis) in patients receiving concomitant neuromuscular-blocking agents and polymyxin antibiotics (e.g., colistimethate, polymyxin B). |
| Fosphenytoin | Phenytoin decreases the effect of muscle relaxant |
| Gentamicin | The agent increases the effect of muscle relaxant |
| Lincomycin | The agent increases the effect of muscle relaxant |
| Mercaptopurine | The agent dereases the effect of the muscle relaxant |
| Netilmicin | The agent increases the effect of muscle relaxant |
| Oxtriphylline | Theophylline decreases the effect of muscle relaxant |
| Phenytoin | Phenytoin decreases the effect of the muscle relaxant |
| Piperacillin | The agent increases the effect of the muscle relaxant |
| Quinidine | The quinine derivative increases the effect of the muscle relaxant |
| Quinine | The quinine derivative increases the effect of the muscle relaxant |
| Theophylline | Theophylline decreases the effect of the muscle relaxant |
| Tobramycin | The agent increases the effect of the muscle relaxant |
食物相互作用
Not Available
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