药品详细
Pargyline(优降宁)
化学结构式图
中文名
优降宁
英文名
Pargyline
分子式
C11H13N
化学名
benzyl(methyl)(prop-2-yn-1-yl)amine
分子量
Average: 159.2276
Monoisotopic: 159.104799421
Monoisotopic: 159.104799421
CAS号
555-57-7
ATC分类
C02K Other Antihypertensives;C02L 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A monoamine oxidase inhibitor with antihypertensive properties. [PubChem]
生产厂家
- Abbott laboratories pharmaceutical products div
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
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适应症
药理
| Indication | For the treatment of moderate to severe hypertension. |
| Pharmacodynamics | Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis. |
| Mechanism of action | MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties | Not Available | |||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Epinephrine | Increased arterial pressure |
| Fenoterol | Increased arterial pressure |
| Guanethidine | Pargyline may decrease the effect of guanethidine. |
| Methotrimeprazine | Possible severe adverse reaction with this combination |
| Milnacipran | Increase serotonin levels. Combination therapy is contraindicated. |
| Orciprenaline | Increased arterial pressure |
| Phenylephrine | Increased arterial pressure |
| Phenylpropanolamine | Increased arterial pressure |
| Pseudoephedrine | Increased arterial pressure |
| Terbutaline | Increased arterial pressure |
食物相互作用
- Food increases the oral bioavailability by 3-5 fold.
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