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药品详细

Paromomycin(巴龙霉素)

化学结构式图
中文名
巴龙霉素
英文名
Paromomycin
分子式
C23H45N5O14
化学名
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol
分子量
Average: 615.6285
Monoisotopic: 615.296301173
CAS号
1263-89-4
ATC分类
A07A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

生产厂家
  • Caraco pharmaceutical laboratories ltd
  • Heritage pharmaceuticals inc
  • King pharmaceuticals inc
  • Parke davis div warner lambert co
  • Parkedale pharmaceuticals inc
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Vicens Q, Westhof E: Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure. 2001 Aug;9(8):647-58. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Aminoglycosides
Substructures
  • Aminoglycosides
  • Glycerol and Derivatives
  • Hydroxy Compounds
  • Pyrans
  • Acetals and Derivatives
  • Aliphatic and Aryl Amines
  • Ethers
  • Alcohols and Polyols
  • Amino Alcohols
  • Heterocyclic compounds
  • Carbohydrates
  • Furans
适应症
药理
Indication For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Pharmacodynamics Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
Mechanism of action Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Absorption Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 7.97e+01 g/l ALOGPS
logP -2.9 ALOGPS
logP -8.3 ChemAxon
logS -0.89 ALOGPS
pKa (strongest acidic) 12.23 ChemAxon
pKa (strongest basic) 9.94 ChemAxon
physiological charge 5 ChemAxon
hydrogen acceptor count 19 ChemAxon
hydrogen donor count 13 ChemAxon
polar surface area 347.32 ChemAxon
rotatable bond count 9 ChemAxon
refractivity 134.24 ChemAxon
polarizability 60.4 ChemAxon
药物相互作用
食物相互作用
  • Take with food.

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