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药品详细

Nitroxoline(Nitroxoline)

化学结构式图
中文名
Nitroxoline
英文名
Nitroxoline
分子式
C9H6N2O3
化学名
5-nitroquinolin-8-ol
分子量
Average: 190.1555
Monoisotopic: 190.037842068
CAS号
4008-48-4
ATC分类
J01X Other Antibacterials
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Aminoquinolines and Derivatives
    • Hydroxyquinolines
    Substructures
    • Hydroxy Compounds
    • Nitrobenzenes
    • Oxoazaniums
    • Phenols and Derivatives
    • Pyridines and Derivatives
    • Nitrophenols and Derivatives
    • Benzene and Derivatives
    • Aminoquinolines and Derivatives
    • Aminophenols and Derivatives
    • Nitro compounds
    • Hydroxyquinolines
    • Heterocyclic compounds
    • Aromatic compounds
    • (Iso)quinolines and Derivatives
    • Phenyl Esters
    • Anilines
    适应症
    药理
    Indication Nitroxoline is an antibiotic agent.
    Pharmacodynamics Not Available
    Mechanism of action This drug may also have antitumor activity by inhibition of ype 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis. Its antibacterial activity may stem from the metal ion complexation vital for bacterial growth.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 180 °C PhysProp
    logP 1.99 HANSCH,C ET AL. (1995)
    Predicted Properties
    Property Value Source
    water solubility 2.73e+00 g/l ALOGPS
    logP 1.9 ALOGPS
    logP 1.77 ChemAxon
    logS -1.8 ALOGPS
    pKa (strongest acidic) 6.88 ChemAxon
    pKa (strongest basic) 2.08 ChemAxon
    physiological charge -1 ChemAxon
    hydrogen acceptor count 4 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 78.94 ChemAxon
    rotatable bond count 1 ChemAxon
    refractivity 49.28 ChemAxon
    polarizability 17.16 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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