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药品详细

Norepinephrine(去甲肾上腺素)

化学结构式图
中文名
去甲肾上腺素
英文名
Norepinephrine
分子式
C8H11NO3
化学名
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
分子量
Average: 169.1778
Monoisotopic: 169.073893223
CAS号
51-41-2
ATC分类
C01C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]

生产厂家
  • Hospira inc
封装厂家
参考
Synthesis Reference Not Available
General Reference Not Available
剂型
规格
化合物类型
Type small molecule
Classes
  • Catecholamines and Derivatives
Substructures
  • Hydroxy Compounds
  • Phenols and Derivatives
  • Benzyl Alcohols and Derivatives
  • Aliphatic and Aryl Amines
  • Benzene and Derivatives
  • Amino Alcohols
  • Catecholamines and Derivatives
  • Catechols
  • Phenethylamines
  • Aromatic compounds
  • Alcohols and Polyols
  • Phenyl Esters
适应症
药理
Indication Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Pharmacodynamics Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance.
Mechanism of action Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available

Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.

Substrate Enzymes Product
Norepinephrine
    		Norepinephrine sulfate Details
    Norepinephrine
      		3-Methoxy-4-Hydroxyphenylglycol sulfate Details
      Route of elimination Not Available
      Half life Not Available
      Clearance Not Available
      Toxicity In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
      Affected organisms
      • Humans and other mammals
      Pathways Not Available
      理化性质
      Properties
      State solid
      Experimental Properties
      Property Value Source
      melting point 217 dec °C PhysProp
      logP -1.24 HANSCH,C ET AL. (1995)
      pKa 8.58 PERRIN,DD (1965)
      Predicted Properties
      Property Value Source
      water solubility 1.25e+01 g/l ALOGPS
      logP -1.4 ALOGPS
      logP -0.68 ChemAxon
      logS -1.1 ALOGPS
      pKa (strongest acidic) 9.5 ChemAxon
      pKa (strongest basic) 8.85 ChemAxon
      physiological charge 1 ChemAxon
      hydrogen acceptor count 4 ChemAxon
      hydrogen donor count 4 ChemAxon
      polar surface area 86.71 ChemAxon
      rotatable bond count 2 ChemAxon
      refractivity 44.46 ChemAxon
      polarizability 16.96 ChemAxon
      药物相互作用
      Drug Interaction
      Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of norepinephrine.
      Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of norepinephrine.
      Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of norepinephrine.
      Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of norepinephrine.
      Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
      Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of norepinephrine.
      Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, norepinephrine.
      Guanethidine Norepinephrine may decrease the effect of guanethidine.
      Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of norepinephrine.
      Isocarboxazid Increased arterial pressure
      Linezolid Possible increase of arterial pressure
      Methyldopa Increased arterial pressure
      Midodrine Increased arterial pressure
      Moclobemide Moclobemide increases the sympathomimetic effect of norepinephrine.
      Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of norepinephrine.
      Phenelzine Increased arterial pressure
      Rasagiline Increased arterial pressure
      Reserpine Increased arterial pressure
      Trimipramine Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Norepinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
      Venlafaxine Venlafaxine may increase the tachycardic and vasopressor effects of Norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
      食物相互作用
      Not Available

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