药品详细
Nystatin(制霉菌素)
化学结构式图
中文名
制霉菌素
英文名
Nystatin
分子式
C47H75NO17
化学名
(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
分子量
Average: 926.0949
Monoisotopic: 925.503499979
Monoisotopic: 925.503499979
CAS号
1400-61-9
ATC分类
A07A 未知;D01A 未知;G01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
生产厂家
- Actavis mid atlantic llc
- Alpharma us pharmaceuticals division
- Altana inc
- Apothecon inc div bristol myers squibb
- Barlan pharmacal co inc
- Bausch and lomb pharmaceuticals inc
- Bayer pharmaceuticals corp
- Bristol myers squibb
- Bristol myers squibb co
- Coastal pharmaceuticals inc
- Dava pharmaceuticals inc
- E fougera div altana inc
- Glenmark generics inc usa
- Holland rantos co inc
- Kv pharmaceutical co
- Lederle laboratories div american cyanamid co
- Morton grove pharmaceuticals inc
- Mutual pharmaceutical co inc
- Odyssey pharmaceuticals inc
- Paddock laboratories inc
- Par pharmaceutical inc
- Perrigo new york inc
- Pharmaderm div altana inc
- Pharmafair inc
- Quantum pharmics ltd
- Roxane laboratories inc
- Sandoz inc
- Savage laboratories inc div altana inc
- Taro pharmaceuticals usa inc
- Teva pharmaceuticals usa inc
- Upsher smith laboratories inc
- Usl pharma inc
- Vintage pharmaceuticals inc
- Vintage pharmaceuticals llc
- Vistapharm inc
- Warner chilcott co llc
- Watson laboratories inc
- Westwood squibb pharmaceuticals inc
- Wockhardt eu operations (swiss) ag
- X gen pharmaceuticals inc
封装厂家
- Actavis Group
- Advanced Pharmaceutical Services Inc.
- Aidarex Pharmacuticals LLC
- Apothecon
- A-S Medication Solutions LLC
- Atlantic Biologicals Corporation
- Bausch & Lomb Inc.
- Bryant Ranch Prepack
- Cardinal Health
- Contract Pharm
- Cutis Pharma Inc.
- Dept Health Central Pharmacy
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Duramed
- E. Fougera and Co.
- E.R. Squibb and Sons LLC
- Gallipot
- Glenmark Generics Ltd.
- Major Pharmaceuticals
- Medisca Inc.
- Metrics Inc.
- Midlothian Labs
- Murfreesboro Pharmaceutical Nursing Supply
- Mutual Pharmaceutical Co.
- Novopharm Ltd.
- Nycomed Inc.
- Odyssey Pharmaceuticals Inc.
- Paddock Labs
- Palmetto Pharmaceuticals Inc.
- Par Pharmaceuticals
- PD-Rx Pharmaceuticals Inc.
- PEDiNOL
- Perrigo Co.
- Pharmaceutical Association
- Pharmaceutics International Inc.
- Pharmedix
- Physicians Total Care Inc.
- Pliva Inc.
- Precision Dose Inc.
- Preferred Pharmaceuticals Inc.
- Qualitest
- Rebel Distributors Corp.
- Sandoz
- Savage Labs
- Stat Scripts LLC
- Taro Pharmaceuticals USA
- Teva Pharmaceutical Industries Ltd.
- USL Pharma Inc.
- Vintage Pharmaceuticals Inc.
- Vistapharm Inc.
- Wockhardt Ltd.
- Xactdose Inc.
- X-Gen Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference |
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剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species |
| Pharmacodynamics | Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses. |
| Mechanism of action | Nystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. |
| Absorption | Nystatin is not absorbed from intact skin or mucous membrane. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
- Take without regard to meals.
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