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药品详细

Nilvadipine(尼伐地平)

化学结构式图
中文名
尼伐地平
英文名
Nilvadipine
分子式
C19H19N3O6
化学名
3-methyl 5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
分子量
Average: 385.3707
Monoisotopic: 385.127385355
CAS号
75530-68-6
ATC分类
C08C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Nilvadipine is a calcium channel blocker (CCB) for treatment of hypertension.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Nitrobenzenes
    Substructures
    • Dihydropyridines
    • Carboxylic Acids and Derivatives
    • Nitrobenzenes
    • Acetates
    • Oxoazaniums
    • Nitriles and Derivatives
    • Ethers
    • Benzene and Derivatives
    • Nitro compounds
    • Enamines
    • Cyanides
    • Heterocyclic compounds
    • Aromatic compounds
    • Anilines
    适应症
    药理
    Indication For the management of vasospastic angina, chronic stable angina and hypertension.
    Pharmacodynamics Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
    Mechanism of action Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.24e-02 g/l ALOGPS
    logP 2.97 ALOGPS
    logP 2.24 ChemAxon
    logS -4.5 ALOGPS
    pKa (strongest basic) -0.57 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 6 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 134.24 ChemAxon
    rotatable bond count 7 ChemAxon
    refractivity 101.8 ChemAxon
    polarizability 37.54 ChemAxon
    药物相互作用
    食物相互作用
    • Take without regard to meals

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