药品详细
Nitric Oxide(一氧化氮)
化学结构式图
中文名
一氧化氮
英文名
Nitric Oxide
分子式
NO
化学名
nitroso
分子量
Average: 30.0061
Monoisotopic: 29.997988627
Monoisotopic: 29.997988627
CAS号
10102-43-9
ATC分类
R07A Other Respiratory System Products
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.
Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.
The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
生产厂家
- Ino therapeutics inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
|
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
药理
| Indication | For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure |
| Pharmacodynamics | Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia. In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale. In neonates with PPHN, Nitric oxide improves oxygenation (as indicated by significant increases in PaO2). Nitric oxide appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better entilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios. |
| Mechanism of action | Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation. |
| Absorption | Nitric oxide is absorbed systemically after inhalation. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
via pulmonary capillary bed
|
| Route of elimination | Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled. |
| Half life | 2–6 seconds |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | liquid | ||||||||||||||||||||||||||||||
| Experimental Properties |
|
||||||||||||||||||||||||||||||
| Predicted Properties |
|
||||||||||||||||||||||||||||||
药物相互作用
食物相互作用
Not Available
收藏