PURPOSE: A pharmaceutical composition containing outer membrane vesicles for anticancer is provided to effectively deliver an anticancer agent into cells and enable cancer treatment of high specificity. CONSTITUTION: An outer membrane vesicles(OMVs) for anti-cancer comprises: an outer membrane proteins(OMPs), a cancer-targeting ligand conjugated to the outer membrane vesicles

The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of...

The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 2',2'-difluorodeoxycytidine (Gemcitabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in the treatment of cancer. The composition has an average particle size in the range of...

The present invention relates to a pharmaceutical composition for the targeted delivery of a pharmaceutically active compound, the composition comprising soft, gas-filled particles having an envelope monolayer comprising one or more surfactants and a pharmaceutically active compound. More particularly, the invention relates to a pharmaceutical composition, wherein the envelope monolayer of the gas-filled particles have a negative overall net charge, and wherein the pharmaceutically active compou...

Disclosed is a method for preparing a pharmaceutical composition of submicron particles of precipitated paclitaxel or its derivative compounds, the solubility of which is greater in a water miscible first solvent than in a second solvent that is aqueous, the method comprising the steps of: (i) mixing into the water-miscible first solvent or the second solvent or both the water miscible first solvent and the second solvent, a first surface modifier comprising a phospholipid conjugated with a wate...

In the present invention compositions and methods are described for treating patients with a hepatitis C viral infection typically using interferon-alpha and/or ribavirin which are incorporated into liposomes, wherein the liposomes typically contain at least one carbohydrate moiety on the surface, such as a mono-, di-, oligo-, or polysaccharide moiety or any combination thereof, for targeting to hepatocytes. Other liposome surface modifications are provided to enhance effectiveness of the compou...

In the present invention compositions and methods are described for treating patients with a hepatitis C viral infection typically using interferon-alpha and/or ribavirin which are incorporated into liposomes, wherein the liposomes typically contain at least one carbohydrate moiety on the surface, such as a mono-, di-, oligo-, or polysaccharide moiety or any combination thereof, for targeting to hepatocytes. Other liposome surface modifications are provided to enhance effectiveness of the compou...

Along circulating non-pegylated liposomal doxorubicin composition for parenteral administration and a process for its preparation. The circulation time in swiss albino mice is at least 25 times longer than conventional non-liposomal compositions. The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models.