专利详细信息
| 专利号 |
 |
| 专利标题 | METHODS FOR TREATING NEURAL CELL SWELLING |
| 专利权人 | UNIV MARYLAND; |
| 发明人 | SIMARD J MARC [US]; CHEN MINGKUI [US]; |
| 申请号 | US201213483824 |
| 申请日 | 2012/5/30 |
| 公开日 | 2012/9/20 |
| 优先权号 |
US20070857547 20070919 US20050099332 20050405 US20030391561 20030320 US20020365933P 20020320 |
| IPC | A61K003118; G01N003350; A61K003100; A61K0031175; A61K0031195; A61K0031197; A61K00314015; A61K0031403; A61K0031404; A61K0031426; A61K00314439; A61K0031451; A61K003164; A61K00317076; A61K004500; A61K004900; A61P002500; A61P002900; A61P004300; B01J001900; B01L000300; B29C006548; B81B000100; C07K001447; C07K0014705; C12N000506; C12N0005079; C12N000508; C12Q000102; G01N0027447; G01N003315; G01N0033566; G01N003368; |
| 专利类型 | |
| 法律状态查询 | 查看法律状态 |
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.
| 专利号 | 专利名称 | 专利权人 | 优先权号 |
|---|---|---|---|
| US2009137680A1 | NOVEL NON-SELECTIVE CATION CHANNEL IN NEURONAL CELLS AND METHOD FOR TREATING BRAIN SWELLING | US20080201610 US20060359946 US20030391561 US20050229236 US20020365933P US20050698272P US20040610758P |
|
| US2008139659A1 | METHODS FOR TREATING NEURAL CELL SWELLING | UNIV MARYLAND [US]; | US20070857547 US20050099332 US20030391561 US20020365933P |
| US2006276411A1 | Novel non-selective cation channel in neuronal cells and methods for treating brain swelling | UNIV MARYLAND [US]; | US20060359946 US20030391561 US20050229236 US20020365933P US20050698272P US20040610758P |
| US2005181980A1 | Novel non-selective cation channel in neural cells and method for treating brain swelling | US20050099332 US20030391561 WO2003US08442 US20020365933P |
|
| WO03079987A2 | A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS AND METHODS FOR TREATING BRAIN SWELLING | UNIV MARYLAND [US];SIMARD J MARC [US];MINGKUI CHEN [US]; | US20020365933P |
| US2003215889A1 | Non-selective cation channel in neural cells and methods for treating brain swelling | US20030391561 US20020365933P |
|
| CA2477812A1 | A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS AND METHODS FOR TREATING BRAIN SWELLING | UNIV MARYLAND [US]; | US20020365933P WO2003US08442 |
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