The invention provides the compositions and the method that are used for the treatment of hyperproliferative epidermal diseases (hyperproliferative dermaldiseases).Concrete is the present invention has instructed the pharmaceutical composition of the local application mainly be comprised of niacin amide vitamin D metabolism thing and calcipotriol (calcipotriol) and this pharmaceutical composition is effective especially in the treatment of psoriasis and other relevant epidermis diseases and disease with in maintaining treatment.

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