专利详细信息
专利号 | US20140051717A1 |
专利标题 | Methods and systems for treatment of migraines and other indications |
专利权人 | Strategic Science & Technologies, Llc; |
发明人 | Fossel, Eric T.; |
申请号 | US14/067441 |
申请日 | 2013/10/30 |
公开日 | 2014/2/20 |
优先权号 | |
IPC | A61K00970000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ergopeptines triptans and other compounds including salts and derivatives of these and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum KELTROL® BT and/or KELTROL® RD) propylene glycol and a polysorbate surfactant such as Polysorbate 20 which combination unexpectedly provides temperature stability to the composition e.g. at elevated temperatures such as at least 40° C. (at least about 104° F.) as compared to compositions lacking one or more of these.
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